Auxiliary Screening COVID-19 by Serology

Background The 2019 novel coronavirus (COVID-19) pandemic remains rampant in many countries/regions. Improving the positive detection rate of COVID-19 infection is an important measure for control and prevention of this pandemic. This meta-analysis aims to systematically summarize the current characteristics of the auxiliary screening methods by serology for COVID-19 infection in real world. Methods Web of Science, Cochrane Library, Embase, PubMed, CNKI, and Wangfang databases were searched for relevant articles published prior to May 1st, 2022. Data on specificity, sensitivity, positive/negative likelihood ratio, area under curve (AUC), and diagnostic odds ratio (dOR) were calculated purposefully. Results Sixty-two studies were included with 35,775 participants in the meta-analysis. Among these studies, the pooled estimates for area under the summary receiver operator characteristic of IgG and IgM to predicting COVID-19 diagnosis were 0.974 and 0.928, respectively. The IgG dOR was 209.78 (95% CI: 106.12 to 414.67). The IgM dOR was 78.17 (95% CI: 36.76 to 166.25). Conclusion Our findings support serum-specific antibody detection may be the main auxiliary screening methods for COVID-19 infection in real world.

Robust optimization model of anti-epidemic supply chain under technological innovation: learning from COVID-19.

The anti-epidemic supply chain plays an important role in the prevention and control of the COVID-19 pandemic. Prior research has focused on studying the facility location, inventory management, and route optimization of the supply chain by using certain parameters and models. Nevertheless, uncertainty, as a vital influence factor, greatly affects the supply chain. As such, the uncertainty that comes with technological innovation has a heightened influence on the supply chain. Few studies have explicitly investigated the influence of technological innovation on the anti-epidemic supply chain under the COVID-19 pandemic. Hence, the current research aims to investigate the influences of the uncertainty caused by technological innovation on the supply chain from demand and supply, shortage penalty, and budget. This paper presents a three-level model of the anti-epidemic supply chain under technological innovation and employs an interval data robust optimization to tackle the uncertainties of the model. The findings are obtained as follows. Firstly, the shortage penalty will increase the costs of the objective function but effectively improve demand satisfaction. Secondly, if the shortage penalty is sufficiently large, the minimum demand satisfaction rate can ensure a fair distribution of materials among the affected areas. Thirdly, technological innovation can reduce costs. The technological innovation related to the transportation costs of the anti-epidemic material distribution center has a greater influence on the optimal value. Meanwhile, the technological innovation related to the transportation costs of the supplier has the least influence. Fourthly, both supply and demand uncertainty can influence costs, but demand uncertainty has a greater influence. Fifthly, the multi-scenario budgeting approach can decrease the calculation complexity. These findings provide theoretical support for anti-epidemic dispatchers to adjust the conservativeness of uncertain parameters under the influence of technological innovation.

Cross-disciplinary approaches to assist with nucleic acid testing for SARS-CoV-2.

Improving the capacity of detecting positive severe acute respiratory syndrome coronavirus 2 is critical for identifying the infection of coronavirus disease 2019 (COVID-19) precisely and thereby curbing the pandemic. Cross-disciplinary approaches may improve the efficiency of COVID-19 diagnosis by compensating to some extent the limitations encountered by traditional test methods during the COVID-19 pandemic. Combining computed tomography (CT), serum-specific antibody detection, and nanopore sequencing with nucleic acid testing for individual testing may improve the accuracy of identifying COVID-19 patients. At community or even regional/national levels, the combination of pooled screening and spatial epidemiological strategies may enable the detection of early transmission of epidemics in a cost-effective way, which is also less affected by restricted access to diagnostic tests and kit supplies. This would significantly advance our capacity of curbing epidemics as soon as possible, and better prepare us for entering a new era of high-impact and high-frequency epidemics.

Spatial technologies to strengthen traditional testing for SARS-CoV-2.

Advanced spatial and digital technologies may help us to take fuller advantage of limited testing resources to monitor the infection status of a large population in a cost-effective manner. Moreover, they may provide additional evidence to supplement results of nucleic acid testing (NAT) for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to decrease false-negative and false-positive rates.